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5FVW

Structure of human nNOS R354A G357D mutant heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl)ethyl) pyridin-2-amine

Summary for 5FVW
Entry DOI10.2210/pdb5fvw/pdb
Related5FVO 5FVP 5FVQ 5FVR 5FVS 5FVT 5FVU 5FVV 5FVX 5FVY 5FVZ 5FW0
DescriptorNITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywordsoxidoreductase, nitric oxide synthase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane, sarcolemma; Peripheral membrane protein: P29475
Total number of polymer chains2
Total formula weight99918.67
Authors
Li, H.,Poulos, T.L. (deposition date: 2016-02-10, release date: 2016-04-20, Last modification date: 2016-06-08)
Primary citationWang, H.,Qin, Y.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59:4913-, 2016
Cited by
PubMed: 27050842
DOI: 10.1021/ACS.JMEDCHEM.6B00273
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

건을2024-03-27부터공개중

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