5FVW
Structure of human nNOS R354A G357D mutant heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl)ethyl) pyridin-2-amine
Summary for 5FVW
Entry DOI | 10.2210/pdb5fvw/pdb |
Related | 5FVO 5FVP 5FVQ 5FVR 5FVS 5FVT 5FVU 5FVV 5FVX 5FVY 5FVZ 5FW0 |
Descriptor | NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total) |
Functional Keywords | oxidoreductase, nitric oxide synthase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane, sarcolemma; Peripheral membrane protein: P29475 |
Total number of polymer chains | 2 |
Total formula weight | 99918.67 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2016-02-10, release date: 2016-04-20, Last modification date: 2024-05-08) |
Primary citation | Wang, H.,Qin, Y.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker. J.Med.Chem., 59:4913-, 2016 Cited by PubMed: 27050842DOI: 10.1021/ACS.JMEDCHEM.6B00273 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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