5FVW

Structure of human nNOS R354A G357D mutant heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl)ethyl) pyridin-2-amine

5FVW の概要

• エントリーDOI: 10.2210/pdb5fvw/pdb
• 関連するPDBエントリー: 5FVO 5FVP 5FVQ 5FVR 5FVS 5FVT 5FVU 5FVV 5FVX 5FVY 5FVZ 5FW0
• 分子名称: NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, nitric oxide synthase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane, sarcolemma; Peripheral membrane protein: P29475
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99918.67

構造登録者

Li, H.,Poulos, T.L. (登録日: 2016-02-10, 公開日: 2016-04-20, 最終更新日: 2016-06-08)

• 主引用文献: Wang, H.,Qin, Y.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.; J.Med.Chem., 59:4913-, 2016; PubMed: 27050842; DOI: 10.1021/ACS.JMEDCHEM.6B00273

実験手法

X-RAY DIFFRACTION (2.2 Å)