5FUT

Human choline kinase a1 in complex with compound 4-(dimethylamino)-1-{4-[4-(4-{[4-(pyrrolidin- 1-yl)pyridinium-1-yl]methyl}phenyl)butyl]benzyl}pyridinium (compound BR25)

Summary for 5FUT

• Entry DOI: 10.2210/pdb5fut/pdb
• Descriptor: CHOLINE KINASE ALPHA, 1,2-ETHANEDIOL, 4-(dimethylamino)-1-{4-[4-(4-{[4-(pyrrolidin-1-yl)pyridinium-1-yl]methyl}phenyl)butyl]benzyl}pyridinium, ... (4 entities in total)
• Functional Keywords: transferase, choline kinase, phosphatidyletanolamine, inhibitors
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 45529.24

Authors

Serran-Aguilera, L.,Denton, H.,Rubio-Ruiz, B.,Lopez-Gutierrez, B.,Entrena, A.,Izquierdo, L.,Smith, T.K.,Conejo-Garcia, A.,Hurtado-Guerrero, R. (deposition date: 2016-01-29, release date: 2016-09-21, Last modification date: 2024-01-10)

• Primary citation: Serran-Aguilera, L.,Denton, H.,Rubio-Ruiz, B.,Lopez-Gutierrez, B.,Entrena, A.,Izquierdo, L.,Smith, T.K.,Conejo-Garcia, A.,Hurtado-Guerrero, R.; Plasmodium Falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death.; Sci.Rep., 6:33189-, 2016; PubMed: 27616047; DOI: 10.1038/SREP33189

Experimental method

X-RAY DIFFRACTION (1.6 Å)