5FUM

Mus musculus acetylcholinesterase in complex with AL200

Summary for 5FUM

Entry DOI	10.2210/pdb5fum/pdb
Descriptor	ACETYLCHOLINESTERASE, 2-(biphenyl-4-yloxy)-1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]ethanone, 2-(2-METHOXYETHOXY)ETHANOL, ... (5 entities in total)
Functional Keywords	hydrolase, acetylcholinesterase, vector control, insecticide, selective, malaria, dengue
Biological source	MUS MUSCULUS (HOUSE MOUSE)
Cellular location	Cell junction, synapse. Isoform H: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side: P21836
Total number of polymer chains	2
Total formula weight	122238.24
Authors	Knutsson, S.,Engdahl, C.,Ekstrom, F.,Linusson, A. (deposition date: 2016-01-28, release date: 2016-09-21, Last modification date: 2018-01-17)
Primary citation	Engdahl, C.,Knutsson, S.,Ekstrom, F.J.,Linusson, A. Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes. J.Med.Chem., 17:2724-, 2016 Cited by PubMed: 27598521 DOI: 10.1021/ACS.JMEDCHEM.6B00967 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation