5FTJ
Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor
Summary for 5FTJ
Entry DOI | 10.2210/pdb5ftj/pdb |
Related | 5FTK 5FTL 5FTM 5FTN |
EMDB information | 3295 |
Descriptor | TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE, ADENOSINE-5'-DIPHOSPHATE, 1-(3-(5-FLUORO-1H-INDOL-2-YL)PHENYL)PIPERIDIN-4-YL)(2-(4-ISOPROPYL-PIPERAZIN1-YL)ETHYL)-CARBAMATE, ... (4 entities in total) |
Functional Keywords | hydrolase, single-particle, p97, aaa atpase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 6 |
Total formula weight | 544529.13 |
Authors | Banerjee, S.,Bartesaghi, A.,Merk, A.,Rao, P.,Bulfer, S.L.,Yan, Y.,Green, N.,Mroczkowski, B.,Neitz, R.J.,Wipf, P.,Falconieri, V.,Deshaies, R.J.,Milne, J.L.S.,Huryn, D.,Arkin, M.,Subramaniam, S. (deposition date: 2016-01-14, release date: 2016-01-27, Last modification date: 2024-05-08) |
Primary citation | Banerjee, S.,Bartesaghi, A.,Merk, A.,Rao, P.,Bulfer, S.L.,Yan, Y.,Green, N.,Mroczkowski, B.,Neitz, R.J.,Wipf, P.,Falconieri, V.,Deshaies, R.J.,Milne, J.L.S.,Huryn, D.,Arkin, M.,Subramaniam, S. 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351:871-, 2016 Cited by PubMed: 26822609DOI: 10.1126/SCIENCE.AAD7974 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.3 Å) |
Structure validation
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