5FTJ

Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE	polymer	806	89436.8	6	UniProt (P55072) Pfam (PF02359) Pfam (PF02933) Pfam (PF00004) Pfam (PF17862)	HOMO SAPIENS (HUMAN)	TER ATPASE, 15S MG(2+)-ATPASE P97 SUBUNIT, VALOSIN-CONTAINING PROTEIN, VCP, P97 VCP TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
2	G, H, J, K, M... (A, B, C, D, E...)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	12	Chemie (ADP)
3	I, L, O, R, U... (A, B, C, D, E...)	1-(3-(5-FLUORO-1H-INDOL-2-YL)PHENYL)PIPERIDIN-4-YL)(2-(4-ISOPROPYL-PIPERAZIN1-YL)ETHYL)-CARBAMATE	non-polymer		463.6	6	Chemie (OJA)
4	AA, BA, CA, DA, Y... (C, D, E, F, A...)	water	water		18.0	120	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	536620.9
Non-Polymers*	Number of molecules	18
	Total formula weight	7908.2
All*	Total formula weight	544529.1

*Water molecules are not included.