5FTJ

Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor

Summary for 5FTJ

• Entry DOI: 10.2210/pdb5ftj/pdb
• Related: 5FTK 5FTL 5FTM 5FTN
• EMDB information: 3295
• Descriptor: TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE, ADENOSINE-5'-DIPHOSPHATE, 1-(3-(5-FLUORO-1H-INDOL-2-YL)PHENYL)PIPERIDIN-4-YL)(2-(4-ISOPROPYL-PIPERAZIN1-YL)ETHYL)-CARBAMATE, ... (4 entities in total)
• Functional Keywords: hydrolase, single-particle, p97, aaa atpase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 6
• Total formula weight: 544529.13

Authors

Banerjee, S.,Bartesaghi, A.,Merk, A.,Rao, P.,Bulfer, S.L.,Yan, Y.,Green, N.,Mroczkowski, B.,Neitz, R.J.,Wipf, P.,Falconieri, V.,Deshaies, R.J.,Milne, J.L.S.,Huryn, D.,Arkin, M.,Subramaniam, S. (deposition date: 2016-01-14, release date: 2016-01-27, Last modification date: 2018-10-03)

• Primary citation: Banerjee, S.,Bartesaghi, A.,Merk, A.,Rao, P.,Bulfer, S.L.,Yan, Y.,Green, N.,Mroczkowski, B.,Neitz, R.J.,Wipf, P.,Falconieri, V.,Deshaies, R.J.,Milne, J.L.S.,Huryn, D.,Arkin, M.,Subramaniam, S.; 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition; Science, 351:871-, 2016; PubMed: 26822609; DOI: 10.1126/SCIENCE.AAD7974

Experimental method

ELECTRON MICROSCOPY (2.3 Å)