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5FPT

Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 2-(1-methyl-1H-indol-3-yl)acetic acid (AT3437) in an alternate binding site.

5FPT の概要
エントリーDOI10.2210/pdb5fpt/pdb
関連するPDBエントリー5FP5 5FP6 5FPD 5FPE 5FPM 5FPN 5FPO 5FPR 5FPS 5FPY
分子名称HEPATITIS C VIRUS FULL-LENGTH NS3 COMPLEX, (1-methyl-1H-indol-3-yl)acetic acid (3 entities in total)
機能のキーワードhepatitis c virus, hcv, ns3 complex, protease-helicase, hydrolase, protein-ligand complex, fragment screening, alternate binding site, at3437.
由来する生物種HEPATITIS C VIRUS (ISOLATE BK)
細胞内の位置Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663
タンパク質・核酸の鎖数2
化学式量合計142117.20
構造登録者
Jhoti, H.,Ludlow, R.F.,Saini, H.K.,Tickle, I.J.,Verdonk, M.,Pathuri, P.,Williams, P.A. (登録日: 2015-12-02, 公開日: 2015-12-23, 最終更新日: 2024-01-10)
主引用文献Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H.
Detection of Secondary Binding Sites in Proteins Using Fragment Screening.
Proc.Natl.Acad.Sci.USA, 112:15910-, 2015
Cited by
PubMed: 26655740
DOI: 10.1073/PNAS.1518946112
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.72 Å)
構造検証レポート
Validation report summary of 5fpt
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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