5FPT
Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 2-(1-methyl-1H-indol-3-yl)acetic acid (AT3437) in an alternate binding site.
5FPT の概要
エントリーDOI | 10.2210/pdb5fpt/pdb |
関連するPDBエントリー | 5FP5 5FP6 5FPD 5FPE 5FPM 5FPN 5FPO 5FPR 5FPS 5FPY |
分子名称 | HEPATITIS C VIRUS FULL-LENGTH NS3 COMPLEX, (1-methyl-1H-indol-3-yl)acetic acid (3 entities in total) |
機能のキーワード | hepatitis c virus, hcv, ns3 complex, protease-helicase, hydrolase, protein-ligand complex, fragment screening, alternate binding site, at3437. |
由来する生物種 | HEPATITIS C VIRUS (ISOLATE BK) |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 142117.20 |
構造登録者 | Jhoti, H.,Ludlow, R.F.,Saini, H.K.,Tickle, I.J.,Verdonk, M.,Pathuri, P.,Williams, P.A. (登録日: 2015-12-02, 公開日: 2015-12-23, 最終更新日: 2024-01-10) |
主引用文献 | Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H. Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112:15910-, 2015 Cited by PubMed: 26655740DOI: 10.1073/PNAS.1518946112 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.72 Å) |
構造検証レポート
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