5FPR
Structure of Bacterial DNA Ligase with small-molecule ligand pyrimidin-2-amine (AT371) in an alternate binding site.
Summary for 5FPR
Entry DOI | 10.2210/pdb5fpr/pdb |
Related | 5FP5 5FP6 5FPD 5FPE 5FPM 5FPN 5FPO 5FPS 5FPT 5FPY |
Descriptor | DNA LIGASE, SULFATE ION, PYRIMIDIN-2-AMINE, ... (4 entities in total) |
Functional Keywords | ligase, antibiotic design, protein-ligand complex, fragment screening, alternate binding site, at371. |
Biological source | STAPHYLOCOCCUS AUREUS |
Total number of polymer chains | 1 |
Total formula weight | 37012.02 |
Authors | Jhoti, H.,Ludlow, R.F.,Pathuri, P.,Saini, H.K.,Tickle, I.J.,Tisi, D.,Verdonk, M.,Williams, P.A. (deposition date: 2015-12-02, release date: 2015-12-16, Last modification date: 2024-01-10) |
Primary citation | Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H. Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112:15910-, 2015 Cited by PubMed: 26655740DOI: 10.1073/PNAS.1518946112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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