5FPL

Crystal structure of human JARID1B in complex with CCT363901

5FPL の概要

• エントリーDOI: 10.2210/pdb5fpl/pdb
• 関連するPDBエントリー: 5FPU 5FPV
• 分子名称: LYSINE-SPECIFIC DEMETHYLASE 5B, LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, MANGANESE (II) ION, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, lysine-specific demethylase 5b
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : Q9UGL1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56004.39

構造登録者

Srikannathasan, V.,Yann-Vai, L.B.,Nowak, R.,Johansson, C.,Gileadi, C.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Brennan, P.,Huber, K.,Oppermann, U. (登録日: 2015-12-02, 公開日: 2016-01-20, 最終更新日: 2024-01-10)

• 主引用文献: Bavetsias, V.,Lanigan, R.M.,Ruda, G.F.,Atrash, B.,Mclaughlin, M.G.,Tumber, A.,Mok, N.Y.,Le Bihan, Y.,Dempster, S.,Boxall, K.J.,Jeganathan, F.,Hatch, S.B.,Savitsky, P.,Velupillai, S.,Krojer, T.,England, K.S.,Sejberg, J.,Thai, C.,Donovan, A.,Pal, A.,Scozzafava, G.,Bennett, J.M.,Kawamura, A.,Johansson, C.,Szykowska, A.,Gileadi, C.,Burgess-Brown, N.A.,von Delft, F.,Oppermann, U.,Walters, Z.,Shipley, J.,Raynaud, F.I.,Westaway, S.M.,Prinjha, R.K.,Fedorov, O.,Burke, R.,Schofield, C.J.,Westwood, I.M.,Bountra, C.,Muller, S.,Van Montfort, R.L.M.,Brennan, P.E.,Blagg, J.; 8-Substituted Pyrido[3,4-D]Pyrimidin-4(3H)-One Derivatives as Potent, Cell Permeable, Kdm4 (Jmjd2) and Kdm5 (Jarid1) Histone Lysine Demethylase Inhibitors.; J.Med.Chem., 59:1388-, 2016; PubMed: 26741168; DOI: 10.1021/ACS.JMEDCHEM.5B01635

実験手法

X-RAY DIFFRACTION (2.35 Å)