5FPG
Crystal structure of human tankyrase 2 in complex with TA-92
Summary for 5FPG
Entry DOI | 10.2210/pdb5fpg/pdb |
Related | 5FPF |
Descriptor | TANKYRASE-2, ZINC ION, 4-[3-(8-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-2- YL)PROPANAMIDO]-N-(QUINOLIN-8-YL)BENZAMIDE, ... (4 entities in total) |
Functional Keywords | transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 55685.37 |
Authors | Haikarainen, T.,Lehtio, L. (deposition date: 2015-11-30, release date: 2016-12-14, Last modification date: 2024-05-08) |
Primary citation | Nathubhai, A.,Haikarainen, T.,Hayward, P.C.,Munoz-Descalzo, S.,Tosh, D.,Lloyd, M.D.,Lehtio, L.,Threadgill, M.D. Design, Synthesis and Evaluation of Novel Dual- Binding Inhibitors of the Tankyrases and Wnt Signalling. To be Published, |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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