5FPG

Crystal structure of human tankyrase 2 in complex with TA-92

Summary for 5FPG

• Entry DOI: 10.2210/pdb5fpg/pdb
• Related: 5FPF
• Descriptor: TANKYRASE-2, ZINC ION, 4-[3-(8-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-2- YL)PROPANAMIDO]-N-(QUINOLIN-8-YL)BENZAMIDE, ... (4 entities in total)
• Functional Keywords: transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 55685.37

Authors

Haikarainen, T.,Lehtio, L. (deposition date: 2015-11-30, release date: 2016-12-14, Last modification date: 2019-10-23)

• Primary citation: Nathubhai, A.,Haikarainen, T.,Hayward, P.C.,Munoz-Descalzo, S.,Tosh, D.,Lloyd, M.D.,Lehtio, L.,Threadgill, M.D.; Design, Synthesis and Evaluation of Novel Dual- Binding Inhibitors of the Tankyrases and Wnt Signalling.; To be Published,

Experimental method

X-RAY DIFFRACTION (2.75 Å)