5FPF
Crystal structure of human tankyrase 2 in complex with TA-91
Summary for 5FPF
Entry DOI | 10.2210/pdb5fpf/pdb |
Related | 5FPG |
Descriptor | TANKYRASE-2, ZINC ION, 4-[3-(4-oxo-3,4-dihydroquinazolin-2- yl)propanamido]-N-(quinolin-8-yl)benzamide, ... (5 entities in total) |
Functional Keywords | transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm: Q9H2K2 Q9H2K2 |
Total number of polymer chains | 4 |
Total formula weight | 55434.96 |
Authors | Haikarainen, T.,Lehtio, L. (deposition date: 2015-11-30, release date: 2016-12-14, Last modification date: 2024-01-10) |
Primary citation | Nathubhai, A.,Haikarainen, T.,Hayward, P.C.,Munoz-Descalzo, S.,Tosh, D.,Lloyd, M.D.,Lehtio, L.,Threadgill, M.D. Design, Synthesis and Evaluation of Novel Dual- Binding Inhibitors of the Tankyrases and Wnt Signalling. To be Published, |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report