5FPF

Crystal structure of human tankyrase 2 in complex with TA-91

Summary for 5FPF

• Entry DOI: 10.2210/pdb5fpf/pdb
• Related: 5FPG
• Descriptor: TANKYRASE-2, ZINC ION, 4-[3-(4-oxo-3,4-dihydroquinazolin-2- yl)propanamido]-N-(quinolin-8-yl)benzamide, ... (5 entities in total)
• Functional Keywords: transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: Q9H2K2 Q9H2K2
• Total number of polymer chains: 4
• Total formula weight: 55434.96

Authors

Haikarainen, T.,Lehtio, L. (deposition date: 2015-11-30, release date: 2016-12-14, Last modification date: 2024-01-10)

• Primary citation: Nathubhai, A.,Haikarainen, T.,Hayward, P.C.,Munoz-Descalzo, S.,Tosh, D.,Lloyd, M.D.,Lehtio, L.,Threadgill, M.D.; Design, Synthesis and Evaluation of Novel Dual- Binding Inhibitors of the Tankyrases and Wnt Signalling.; To be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)