5FOA

Crystal Structure of Human Complement C3b in complex with DAF (CCP2-4)

Summary for 5FOA

Related5FO7 5FO8 5FO9 5FOB
DescriptorCOMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, CD55 (3 entities in total)
Functional Keywordslipid binding, complement system, immune system, plasma protein, regulators of complement activity, decay-accelerating activity
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01024 P08174
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 3: Secreted . Isoform 4: Secreted . Isoform 5: Secreted . Isoform 6: Cell membrane ; Lipid-anchor, GPI-anchor . Isoform 7: Cell membrane ; Lipid-anchor, GPI-anchor  P01024
Total number of polymer chains6
Total molecular weight393516.7
Authors
Forneris, F.,Wu, J.,Xue, X.,Gros, P. (deposition date: 2015-11-18, release date: 2016-04-06, Last modification date: 2016-06-01)
Primary citation
Forneris, F.,Wu, J.,Xue, X.,Ricklin, D.,Lin, Z.,Sfyroera, G.,Tzekou, A.,Volokhina, E.,Granneman, J.C.,Hauhart, R.,Bertram, P.,Liszewski, M.K.,Atkinson, J.P.,Lambris, J.D.,Gros, P.
Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35:1133-, 2016
PubMed: 27013439 (PDB entries with the same primary citation)
DOI: 10.15252/EMBJ.201593673
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (4.188 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.308391.8%9.2%3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution