5FO8

Crystal Structure of Human Complement C3b in Complex with MCP (CCP1-4)

Summary for 5FO8

Related5FO7 5FO9 5FOA 5FOB
DescriptorCOMPLEMENT C3, MEMBRANE COFACTOR PROTEIN, N-ACETYL-D-GLUCOSAMINE, ... (7 entities in total)
Functional Keywordslipid binding, lipid bianding, complement system, immune system, plasma protein, cofa activity, regulators of complement activity
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01024 P15529
Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane ; Single- pass type I membrane protein  P01024
Total number of polymer chains3
Total molecular weight206982.12
Authors
Forneris, F.,Wu, J.,Xue, X.,Gros, P. (deposition date: 2015-11-18, release date: 2016-04-06, Last modification date: 2016-06-01)
Primary citation
Forneris, F.,Wu, J.,Xue, X.,Ricklin, D.,Lin, Z.,Sfyroera, G.,Tzekou, A.,Volokhina, E.,Granneman, J.C.,Hauhart, R.,Bertram, P.,Liszewski, M.K.,Atkinson, J.P.,Lambris, J.D.,Gros, P.
Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35:1133-, 2016
PubMed: 27013439 (PDB entries with the same primary citation)
DOI: 10.15252/EMBJ.201593673
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22150.1%4.2%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution