5FLF

DISEASE LINKED MUTATION IN FGFR

5FLF の概要

• エントリーDOI: 10.2210/pdb5flf/pdb
• 分子名称: FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION, ACETATE ION, ... (6 entities in total)
• 機能のキーワード: transferase, auto-activating, cancer, growth factor, receptor, mutation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P11362
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 177743.93

構造登録者

Thiyagarajan, N.,Bunney, T.D.,Katan, M. (登録日: 2015-10-26, 公開日: 2016-03-30, 最終更新日: 2024-01-10)

• 主引用文献: Patani, H.,Bunney, T.D.,Thiyagarajan, N.,Norman, R.A.,Ogg, D.,Breed, J.,Ashford, P.,Potterton, A.,Edwards, M.,Williams, S.V.,Thomson, G.S.,Pang, C.S.,Knowles, M.A.,Breeze, A.L.,Orengo, C.,Phillips, C.,Katan, M.; Landscape of Activating Cancer Mutations in Fgfr Kinases and Their Differential Responses to Inhibitors in Clinical Use.; Oncotarget, 7:24252-, 2016; PubMed: 26992226; DOI: 10.18632/ONCOTARGET.8132

実験手法

X-RAY DIFFRACTION (2.58 Å)