5FH8

Crystal structure of the fifth bromodomain of human PB1 in complex with compound 28

5FH8 の概要

• エントリーDOI: 10.2210/pdb5fh8/pdb
• 分子名称: Protein polybromo-1, 6-chloranyl-3-(2-ethylbutyl)-4~{H}-pyrrolo[1,2-a]quinazolin-5-one, DIMETHYL SULFOXIDE, ... (5 entities in total)
• 機能のキーワード: pbrm1, brg1-associated factor 180, transcription, chromatin remodeling
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q86U86
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 59943.40

構造登録者

Tallant, C.,Sutherell, C.L.,Siejka, P.,Sorrell, F.J.,Krojer, T.,Picaud, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Ley, S.V.,Knapp, S. (登録日: 2015-12-21, 公開日: 2016-06-01, 最終更新日: 2024-01-10)

• 主引用文献: Sutherell, C.L.,Tallant, C.,Monteiro, O.P.,Yapp, C.,Fuchs, J.E.,Fedorov, O.,Siejka, P.,Muller, S.,Knapp, S.,Brenton, J.D.,Brennan, P.E.,Ley, S.V.; Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.; J.Med.Chem., 59:5095-5101, 2016; PubMed: 27119626; DOI: 10.1021/acs.jmedchem.5b01997

実験手法

X-RAY DIFFRACTION (1.55 Å)