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5FH7

Crystal structure of the fifth bromodomain of human PB1 in complex with compound 18

Summary for 5FH7
Entry DOI10.2210/pdb5fh7/pdb
DescriptorProtein polybromo-1, 1,2-ETHANEDIOL, 6-chloranyl-3-[(dimethylamino)methyl]-4~{H}-pyrrolo[1,2-a]quinazolin-5-one, ... (4 entities in total)
Functional Keywordspbrm1, brg1-associated factor 180, transcription, chromatin remodeling
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: Q86U86
Total number of polymer chains2
Total formula weight29971.60
Authors
Primary citationSutherell, C.L.,Tallant, C.,Monteiro, O.P.,Yapp, C.,Fuchs, J.E.,Fedorov, O.,Siejka, P.,Muller, S.,Knapp, S.,Brenton, J.D.,Brennan, P.E.,Ley, S.V.
Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.
J.Med.Chem., 59:5095-5101, 2016
Cited by
PubMed: 27119626
DOI: 10.1021/acs.jmedchem.5b01997
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.47 Å)
Structure validation

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