5FGC
Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.8
Summary for 5FGC
Entry DOI | 10.2210/pdb5fgc/pdb |
Related | 5FGB |
Descriptor | Genome polyprotein, Anti-HCV E2 Fab HC33.8 light chain, Anti-HCV E2 Fab HC33.8 heavy chain, ... (4 entities in total) |
Functional Keywords | fab fragment, neutralizing antibody, hepatitis c virus e2, viral protein |
Biological source | Homo sapiens More |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P27958 |
Total number of polymer chains | 3 |
Total formula weight | 54444.98 |
Authors | Girard-Blanc, C.,Rey, F.A.,Krey, T. (deposition date: 2015-12-20, release date: 2016-01-20, Last modification date: 2016-03-09) |
Primary citation | Keck, Z.Y.,Girard-Blanc, C.,Wang, W.,Lau, P.,Zuiani, A.,Rey, F.A.,Krey, T.,Diamond, M.S.,Foung, S.K. Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus. J.Virol., 90:3112-3122, 2016 Cited by PubMed: 26739044DOI: 10.1128/JVI.02458-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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