5FGC

Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.8

5FGC の概要

• エントリーDOI: 10.2210/pdb5fgc/pdb
• 関連するPDBエントリー: 5FGB
• 分子名称: Genome polyprotein, Anti-HCV E2 Fab HC33.8 light chain, Anti-HCV E2 Fab HC33.8 heavy chain, ... (4 entities in total)
• 機能のキーワード: fab fragment, neutralizing antibody, hepatitis c virus e2, viral protein
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P27958
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 54444.98

構造登録者

Girard-Blanc, C.,Rey, F.A.,Krey, T. (登録日: 2015-12-20, 公開日: 2016-01-20, 最終更新日: 2016-03-09)

• 主引用文献: Keck, Z.Y.,Girard-Blanc, C.,Wang, W.,Lau, P.,Zuiani, A.,Rey, F.A.,Krey, T.,Diamond, M.S.,Foung, S.K.; Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus.; J.Virol., 90:3112-3122, 2016; PubMed: 26739044; DOI: 10.1128/JVI.02458-15

実験手法

X-RAY DIFFRACTION (1.9 Å)