5FDO

Mcl-1 complexed with small molecule inhibitor

Summary for 5FDO

Entry DOI	10.2210/pdb5fdo/pdb
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, 3-[3-(4-chloranyl-3,5-dimethyl-phenoxy)propyl]-~{N}-(phenylsulfonyl)-1~{H}-indole-2-carboxamide (2 entities in total)
Functional Keywords	mcl-1, inhibitor, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	70590.31
Authors	Zhao, B. (deposition date: 2015-12-16, release date: 2016-03-02, Last modification date: 2023-09-27)
Primary citation	Pelz, N.F.,Bian, Z.,Zhao, B.,Shaw, S.,Tarr, J.C.,Belmar, J.,Gregg, C.,Camper, D.V.,Goodwin, C.M.,Arnold, A.L.,Sensintaffar, J.L.,Friberg, A.,Rossanese, O.W.,Lee, T.,Olejniczak, E.T.,Fesik, S.W. Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods. J.Med.Chem., 59:2054-2066, 2016 Cited by PubMed: 26878343 DOI: 10.1021/acs.jmedchem.5b01660 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation