5FDO

Mcl-1 complexed with small molecule inhibitor

5FDO の概要

• エントリーDOI: 10.2210/pdb5fdo/pdb
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, 3-[3-(4-chloranyl-3,5-dimethyl-phenoxy)propyl]-~{N}-(phenylsulfonyl)-1~{H}-indole-2-carboxamide (2 entities in total)
• 機能のキーワード: mcl-1, inhibitor, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 70590.31

構造登録者

Zhao, B. (登録日: 2015-12-16, 公開日: 2016-03-02, 最終更新日: 2023-09-27)

• 主引用文献: Pelz, N.F.,Bian, Z.,Zhao, B.,Shaw, S.,Tarr, J.C.,Belmar, J.,Gregg, C.,Camper, D.V.,Goodwin, C.M.,Arnold, A.L.,Sensintaffar, J.L.,Friberg, A.,Rossanese, O.W.,Lee, T.,Olejniczak, E.T.,Fesik, S.W.; Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.; J.Med.Chem., 59:2054-2066, 2016; PubMed: 26878343; DOI: 10.1021/acs.jmedchem.5b01660

実験手法

X-RAY DIFFRACTION (2.8 Å)