5FDI

Crystal structure of Human Carbonic Anhydrase II with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog.

Summary for 5FDI

• Entry DOI: 10.2210/pdb5fdi/pdb
• Related: 1CA2
• Descriptor: Carbonic anhydrase 2, ZINC ION, 1,1-bis(oxidanylidene)-3-[(sulfamoylamino)methyl]-1-benzothiophene, ... (6 entities in total)
• Functional Keywords: sulfamide inhibitor, protein-inhibitor complex, lyase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P00918
• Total number of polymer chains: 1
• Total formula weight: 30059.59

Authors

Di Fiore, A.,De Simone, G.,Alterio, V.,Riccio, V.,Winum, J.-Y.,Carta, F.,Supuran, C.T. (deposition date: 2015-12-16, release date: 2016-05-18, Last modification date: 2024-01-10)

• Primary citation: Di Fiore, A.,De Simone, G.,Alterio, V.,Riccio, V.,Winum, J.Y.,Carta, F.,Supuran, C.T.; The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies.; Org.Biomol.Chem., 14:4853-4858, 2016; PubMed: 27151329; DOI: 10.1039/c6ob00803h

Experimental method

X-RAY DIFFRACTION (1.85 Å)