5FDC
Crystal structure of Human Carbonic Anhydrase II in complex with the anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog.
Summary for 5FDC
| Entry DOI | 10.2210/pdb5fdc/pdb |
| Related | 1CA2 |
| Descriptor | Carbonic anhydrase 2, ZINC ION, 3-[(sulfamoylamino)methyl]-1-benzothiophene, ... (6 entities in total) |
| Functional Keywords | sulfamide inhibitor, protein-inhibitor complex, lyase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 30027.59 |
| Authors | Di Fiore, A.,De Simone, G.,Alterio, V.,Riccio, V.,Winum, J.-Y.,Carta, F.,Supuran, C.T. (deposition date: 2015-12-16, release date: 2016-05-18, Last modification date: 2024-01-10) |
| Primary citation | Di Fiore, A.,De Simone, G.,Alterio, V.,Riccio, V.,Winum, J.Y.,Carta, F.,Supuran, C.T. The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies. Org.Biomol.Chem., 14:4853-4858, 2016 Cited by PubMed: 27151329DOI: 10.1039/c6ob00803h PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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