5FCR

MOUSE COMPLEMENT FACTOR D

Summary for 5FCR

Entry DOI	10.2210/pdb5fcr/pdb
Descriptor	Complement factor D, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... (6 entities in total)
Functional Keywords	hydrolase
Biological source	Mus musculus (House Mouse)
Cellular location	Secreted: P03953
Total number of polymer chains	4
Total formula weight	102767.76
Authors	Mac Sweeney, A. (deposition date: 2015-12-15, release date: 2016-10-26, Last modification date: 2024-01-10)
Primary citation	Maibaum, J.,Liao, S.M.,Vulpetti, A.,Ostermann, N.,Randl, S.,Rudisser, S.,Lorthiois, E.,Erbel, P.,Kinzel, B.,Kolb, F.A.,Barbieri, S.,Wagner, J.,Durand, C.,Fettis, K.,Dussauge, S.,Hughes, N.,Delgado, O.,Hommel, U.,Gould, T.,Mac Sweeney, A.,Gerhartz, B.,Cumin, F.,Flohr, S.,Schubart, A.,Jaffee, B.,Harrison, R.,Risitano, A.M.,Eder, J.,Anderson, K. Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat.Chem.Biol., 12:1105-1110, 2016 Cited by PubMed: 27775713 DOI: 10.1038/nchembio.2208 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation