5FCR

MOUSE COMPLEMENT FACTOR D

Summary for 5FCR

DescriptorComplement factor D, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... (6 entities in total)
Functional Keywordshydrolase
Biological sourceMus musculus (House Mouse)
Cellular locationSecreted P03953
Total number of polymer chains4
Total molecular weight102767.76
Authors
Mac Sweeney, A. (deposition date: 2015-12-15, release date: 2016-10-26, Last modification date: 2016-11-23)
Primary citation
Maibaum, J.,Liao, S.M.,Vulpetti, A.,Ostermann, N.,Randl, S.,Rudisser, S.,Lorthiois, E.,Erbel, P.,Kinzel, B.,Kolb, F.A.,Barbieri, S.,Wagner, J.,Durand, C.,Fettis, K.,Dussauge, S.,Hughes, N.,Delgado, O.,Hommel, U.,Gould, T.,Mac Sweeney, A.,Gerhartz, B.,Cumin, F.,Flohr, S.,Schubart, A.,Jaffee, B.,Harrison, R.,Risitano, A.M.,Eder, J.,Anderson, K.
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat.Chem.Biol., 12:1105-1110, 2016
PubMed: 27775713 (PDB entries with the same primary citation)
DOI: 10.1038/nchembio.2208
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.25 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.203601.4%0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution