5FBX

Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor

Summary for 5FBX

• Entry DOI: 10.2210/pdb5fbx/pdb
• Descriptor: Bromodomain-containing protein 4, (3~{S})-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methyl-3-phenyl-3~{H}-isoindol-1-one (3 entities in total)
• Functional Keywords: brg1-associated factor 180, baf180, transcription, chromatin remodeling
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 15417.75

Authors

Tallant, C.,Clark, P.G.K.,Siejka, P.,Fedorov, O.,Nowak, R.,Srikannathasan, V.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Brennan, P.E.,Dixon, D.,Knapp, S. (deposition date: 2015-12-14, release date: 2015-12-30, Last modification date: 2024-01-10)

• Primary citation: Tallant, C.,Clark, P.G.K.,Siejka, P.,Fedorov, O.,Nowak, R.,Srikannathasan, V.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Brennan, P.E.,Dixon, D.,Knapp, S.; Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)