5FBX

Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 5W4 A 201

Chain	Residue
A	TRP81
A	HOH316
A	PRO82
A	PHE83
A	LEU92
A	LYS99
A	ASN140
A	MET149
A	HOH308
A	HOH311

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

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