5FBK

Crystal structure of the extracellular domain of human calcium sensing receptor

Summary for 5FBK

Related5FBH
DescriptorExtracellular calcium-sensing receptor, CYCLOMETHYLTRYPTOPHAN, N-ACETYL-D-GLUCOSAMINE, ... (7 entities in total)
Functional Keywordsmembrane protein, g-protein coupled receptor, ectodomain, signaling protein
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Multi-pass membrane protein  P41180
Total number of polymer chains2
Total molecular weight131040.57
Authors
Zhang, T.,Zhang, C.,Miller, C.L.,Zou, J.,Moremen, K.W.,Brown, E.M.,Yang, J.J.,Hu, J. (deposition date: 2015-12-14, release date: 2016-06-22, Last modification date: 2016-07-20)
Primary citation
Zhang, C.,Zhang, T.,Zou, J.,Miller, C.L.,Gorkhali, R.,Yang, J.Y.,Schilmiller, A.,Wang, S.,Huang, K.,Brown, E.M.,Moremen, K.W.,Hu, J.,Yang, J.J.
Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
Sci Adv, 2:e1600241-e1600241, 2016
PubMed: 27386547 (PDB entries with the same primary citation)
DOI: 10.1126/sciadv.1600241
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.230405.6%7.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report