5F9E

Structure of Protein Kinase C theta with compound 10: 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one

5F9E の概要

• エントリーDOI: 10.2210/pdb5f9e/pdb
• 分子名称: Protein kinase C theta type, 2,2-dimethyl-7-(2-oxidanylidene-3~{H}-imidazo[4,5-b]pyridin-1-yl)-1-(phenylmethyl)-3~{H}-quinazolin-4-one (3 entities in total)
• 機能のキーワード: kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q04759
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84709.20

構造登録者

Klein, M. (登録日: 2015-12-09, 公開日: 2016-05-11)

• 主引用文献: Katoh, T.,Takai, T.,Yukawa, T.,Tsukamoto, T.,Watanabe, E.,Mototani, H.,Arita, T.,Hayashi, H.,Nakagawa, H.,Klein, M.G.,Zou, H.,Sang, B.C.,Snell, G.,Nakada, Y.; Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKC theta inhibitors.; Bioorg.Med.Chem., 24:2466-2475, 2016; PubMed: 27117263; DOI: 10.1016/j.bmc.2016.04.008

実験手法

X-RAY DIFFRACTION (2 Å)