5F96

Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235.12 in complex with HIV-1 clade A/E 93TH057 gp120

Summary for 5F96

• Entry DOI: 10.2210/pdb5f96/pdb
• Related: 4RWY 4RX4 4YFL
• Descriptor: clade A/E 93TH057 HIV-1 gp120 core, HEAVY CHAIN OF ANTIBODY CH235.12, LIGHT CHAIN OF ANTIBODY CH235.12, ... (6 entities in total)
• Functional Keywords: hiv-1, antibody, ch235 lineage, vh1-46 germline, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 3
• Total formula weight: 90351.21

Authors

Zhou, T.,Kwong, P.D. (deposition date: 2015-12-09, release date: 2016-03-09, Last modification date: 2020-07-29)

• Primary citation: Bonsignori, M.,Zhou, T.,Sheng, Z.,Chen, L.,Gao, F.,Joyce, M.G.,Ozorowski, G.,Chuang, G.Y.,Schramm, C.A.,Wiehe, K.,Alam, S.M.,Bradley, T.,Gladden, M.A.,Hwang, K.K.,Iyengar, S.,Kumar, A.,Lu, X.,Luo, K.,Mangiapani, M.C.,Parks, R.J.,Song, H.,Acharya, P.,Bailer, R.T.,Cao, A.,Druz, A.,Georgiev, I.S.,Kwon, Y.D.,Louder, M.K.,Zhang, B.,Zheng, A.,Hill, B.J.,Kong, R.,Soto, C.,Mullikin, J.C.,Douek, D.C.,Montefiori, D.C.,Moody, M.A.,Shaw, G.M.,Hahn, B.H.,Kelsoe, G.,Hraber, P.T.,Korber, B.T.,Boyd, S.D.,Fire, A.Z.,Kepler, T.B.,Shapiro, L.,Ward, A.B.,Mascola, J.R.,Liao, H.X.,Kwong, P.D.,Haynes, B.F.; Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.; Cell, 165:449-463, 2016; PubMed: 26949186; DOI: 10.1016/j.cell.2016.02.022

Experimental method

X-RAY DIFFRACTION (2.2407 Å)