5F83

Imipenem complex of the GES-5 C69G mutant

Summary for 5F83

• Entry DOI: 10.2210/pdb5f83/pdb
• Related: 5F82
• Descriptor: Beta-lactamase, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid (3 entities in total)
• Functional Keywords: antibiotic resistance, hydrolase, carbapenemase, imipenem, mutant, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 58728.43

Authors

Smith, C.A.,Vakulenko, S.B. (deposition date: 2015-12-09, release date: 2016-09-07, Last modification date: 2019-12-11)

• Primary citation: Smith, C.A.,Nossoni, Z.,Toth, M.,Stewart, N.K.,Frase, H.,Vakulenko, S.B.; Role of the Conserved Disulfide Bridge in Class A Carbapenemases.; J.Biol.Chem., 291:22196-22206, 2016; PubMed: 27590339; DOI: 10.1074/jbc.M116.749648

Experimental method

X-RAY DIFFRACTION (1.38 Å)