5F6L

The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L

5F6L の概要

• エントリーDOI: 10.2210/pdb5f6l/pdb
• 関連するPDBエントリー: 5F59 5F5E 5F6K
• 分子名称: Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A, ... (6 entities in total)
• 機能のキーワード: histone methyltransferase, histone methylation, set domain, protein complex, protein binding-transferase complex, protein binding/transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : Q15291 Q9UBL3; Nucleus . MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 42545.69

構造登録者

Li, Y.,Lei, M.,Chen, Y. (登録日: 2015-12-06, 公開日: 2016-02-24, 最終更新日: 2023-11-08)

• 主引用文献: Li, Y.,Han, J.,Zhang, Y.,Cao, F.,Liu, Z.,Li, S.,Wu, J.,Hu, C.,Wang, Y.,Shuai, J.,Chen, J.,Cao, L.,Li, D.,Shi, P.,Tian, C.,Zhang, J.,Dou, Y.,Li, G.,Chen, Y.,Lei, M.; Structural basis for activity regulation of MLL family methyltransferases.; Nature, 530:447-452, 2016; PubMed: 26886794; DOI: 10.1038/nature16952

実験手法

X-RAY DIFFRACTION (1.9 Å)