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5F5C

Crystal Structure of human JMJD2D complexed with KDOPP7

Summary for 5F5C
Entry DOI10.2210/pdb5f5c/pdb
DescriptorLysine-specific demethylase 4D, ZINC ION, NICKEL (II) ION, ... (7 entities in total)
Functional Keywordsdouble-stranded beta helix, demethylase, oxygenase, oxidoreductase, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : Q6B0I6
Total number of polymer chains1
Total formula weight41006.28
Authors
Primary citationBavetsias, V.,Lanigan, R.M.,Ruda, G.F.,Atrash, B.,McLaughlin, M.G.,Tumber, A.,Mok, N.Y.,Le Bihan, Y.V.,Dempster, S.,Boxall, K.J.,Jeganathan, F.,Hatch, S.B.,Savitsky, P.,Velupillai, S.,Krojer, T.,England, K.S.,Sejberg, J.,Thai, C.,Donovan, A.,Pal, A.,Scozzafava, G.,Bennett, J.M.,Kawamura, A.,Johansson, C.,Szykowska, A.,Gileadi, C.,Burgess-Brown, N.A.,von Delft, F.,Oppermann, U.,Walters, Z.,Shipley, J.,Raynaud, F.I.,Westaway, S.M.,Prinjha, R.K.,Fedorov, O.,Burke, R.,Schofield, C.J.,Westwood, I.M.,Bountra, C.,Muller, S.,van Montfort, R.L.,Brennan, P.E.,Blagg, J.
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
J.Med.Chem., 59:1388-1409, 2016
Cited by
PubMed: 26741168
DOI: 10.1021/acs.jmedchem.5b01635
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.88 Å)
Structure validation

218500

건을2024-04-17부터공개중

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