5F19
The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2
Summary for 5F19
Entry DOI | 10.2210/pdb5f19/pdb |
Related | 5F1A |
Descriptor | Prostaglandin G/H synthase 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | membrane protein, cyclooxygenase, cyxlooxygenase-2, monotopic, aspirin, complex, covalent inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 132205.01 |
Authors | Lucido, M.J.,Orlando, B.J.,Malkowski, M.G. (deposition date: 2015-11-30, release date: 2016-03-16, Last modification date: 2023-09-27) |
Primary citation | Lucido, M.J.,Orlando, B.J.,Vecchio, A.J.,Malkowski, M.G. Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry, 55:1226-1238, 2016 Cited by PubMed: 26859324DOI: 10.1021/acs.biochem.5b01378 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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