5F19
The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Prostaglandin G/H synthase 2 | polymer | 552 | 63596.6 | 2 | UniProt (P35354) Pfam (PF03098) | Homo sapiens (Human) | Cyclooxygenase-2,COX-2,PHS II,Prostaglandin H2 synthase 2,PGHS-2,Prostaglandin-endoperoxide synthase 2 |
| 2 | C, D (C, D) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G62182OO) | |||
| 3 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | F, R (A, B) | PROTOPORPHYRIN IX CONTAINING CO | non-polymer | 619.6 | 2 | Chemie (COH) | |||
| 5 | G, H, S (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | I, J, T, U (A, B) | ACRYLIC ACID | non-polymer | 72.1 | 4 | Chemie (AKR) | |||
| 7 | AA, BA, CA, K, L... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 15 | Chemie (EDO) | |||
| 8 | DA (B) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 1 | Chemie (BOG) | |||
| 9 | EA, FA (A, B) | water | water | 18.0 | 701 | Chemie (HOH) |
Sequence modifications
A, B: 34 - 583 (UniProt: P35354)
| PDB | External Database | Details |
|---|---|---|
| Lys 33 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 127193.1 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1597.5 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 3414.4 | |
| All* | Total formula weight | 132205.0 |
