5F0F

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound 15 at 1.76A resolution

Summary for 5F0F

Entry DOI	10.2210/pdb5f0f/pdb
Descriptor	HTH-type transcriptional regulator EthR, 4-[4-(3-oxidanylidene-3-pyrrolidin-1-yl-propyl)piperidin-1-yl]benzenecarbonitrile, SULFATE ION, ... (4 entities in total)
Functional Keywords	ethr, transcription, repressor, mycobacterium tuberculosis
Biological source	Mycobacterium tuberculosis CDC1551
Total number of polymer chains	1
Total formula weight	25666.74
Authors	Surade, S.,Blaszczyk, M.,Nikiforov, P.O.,Abell, C.,Blundell, T.L. (deposition date: 2015-11-27, release date: 2016-02-03, Last modification date: 2024-01-10)
Primary citation	Nikiforov, P.O.,Surade, S.,Blaszczyk, M.,Delorme, V.,Brodin, P.,Baulard, A.R.,Blundell, T.L.,Abell, C. A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Org.Biomol.Chem., 14:2318-2326, 2016 Cited by PubMed: 26806381 DOI: 10.1039/c5ob02630j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation