5F03

TRYPTASE B2 IN COMPLEX WITH 5-(3-Aminomethyl-phenoxymethyl)-3-[3-(2-chloro-pyridin-3-ylethynyl)-phenyl]-oxazolidin-2-one; compound with trifluoro-acetic acid

Summary for 5F03

• Entry DOI: 10.2210/pdb5f03/pdb
• Descriptor: Tryptase beta-2, (5~{S})-5-[[3-(aminomethyl)phenoxy]methyl]-3-[3-[2-(2-chloranylpyridin-3-yl)ethynyl]phenyl]-1,3-oxazolidin-2-one (3 entities in total)
• Functional Keywords: human tryptase, serine proteinase, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 55850.63

Authors

Banner, D.,Benz, J.,Joseph, C.,Kuglstatter, A. (deposition date: 2015-11-27, release date: 2016-02-24, Last modification date: 2019-03-20)

• Primary citation: Kuhn, B.,Guba, W.,Hert, J.,Banner, D.,Bissantz, C.,Ceccarelli, S.,Haap, W.,Korner, M.,Kuglstatter, A.,Lerner, C.,Mattei, P.,Neidhart, W.,Pinard, E.,Rudolph, M.G.,Schulz-Gasch, T.,Woltering, T.,Stahl, M.; A Real-World Perspective on Molecular Design.; J.Med.Chem., 59:4087-4102, 2016; PubMed: 26878596; DOI: 10.1021/acs.jmedchem.5b01875

Experimental method

X-RAY DIFFRACTION (1.94 Å)