5EZV
X-ray crystal structure of AMP-activated protein kinase alpha-2/alpha-1 RIM chimaera (alpha-2(1-347)/alpha-1(349-401)/alpha-2(397-end) beta-1 gamma-1) co-crystallized with C2 (5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid)
Summary for 5EZV
Entry DOI | 10.2210/pdb5ezv/pdb |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-2/alpha-1 RIM SWAP chimera, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total) |
Functional Keywords | transferase, serine/threonine kinase, allosteric activation, nucleotide-binding |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : P54646 |
Total number of polymer chains | 6 |
Total formula weight | 267844.05 |
Authors | Langendorf, C.G.,Kemp, B.E. (deposition date: 2015-11-26, release date: 2016-03-09, Last modification date: 2023-09-27) |
Primary citation | Langendorf, C.G.,Ngoei, K.R.,Scott, J.W.,Ling, N.X.,Issa, S.M.,Gorman, M.A.,Parker, M.W.,Sakamoto, K.,Oakhill, J.S.,Kemp, B.E. Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. Nat Commun, 7:10912-10912, 2016 Cited by PubMed: 26952388DOI: 10.1038/ncomms10912 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.99 Å) |
Structure validation
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