5EZV

X-ray crystal structure of AMP-activated protein kinase alpha-2/alpha-1 RIM chimaera (alpha-2(1-347)/alpha-1(349-401)/alpha-2(397-end) beta-1 gamma-1) co-crystallized with C2 (5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid)

5EZV の概要

• エントリーDOI: 10.2210/pdb5ezv/pdb
• 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-2/alpha-1 RIM SWAP chimera, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total)
• 機能のキーワード: transferase, serine/threonine kinase, allosteric activation, nucleotide-binding
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm : P54646
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 267844.05

構造登録者

Langendorf, C.G.,Kemp, B.E. (登録日: 2015-11-26, 公開日: 2016-03-09, 最終更新日: 2023-09-27)

• 主引用文献: Langendorf, C.G.,Ngoei, K.R.,Scott, J.W.,Ling, N.X.,Issa, S.M.,Gorman, M.A.,Parker, M.W.,Sakamoto, K.,Oakhill, J.S.,Kemp, B.E.; Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.; Nat Commun, 7:10912-10912, 2016; PubMed: 26952388; DOI: 10.1038/ncomms10912

実験手法

X-RAY DIFFRACTION (2.99 Å)