5EWM

CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2B IN COMPLEX WITH EVT-101

5EWM の概要

• エントリーDOI: 10.2210/pdb5ewm/pdb
• 関連するPDBエントリー: 5WMJ 5WML
• 分子名称: NMDA glutamate receptor subunit, Glutamate receptor ionotropic, NMDA 2B, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: glutamate receptor, allosteric modulator, glun2b antagonists, transport protein
• 由来する生物種: Xenopus laevis (African clawed frog); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 173209.37

構造登録者

Pandit, J. (登録日: 2015-11-20, 公開日: 2016-03-02, 最終更新日: 2023-09-27)

• 主引用文献: Stroebel, D.,Buhl, D.L.,Knafels, J.D.,Chanda, P.K.,Green, M.,Sciabola, S.,Mony, L.,Paoletti, P.,Pandit, J.; A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.; Mol.Pharmacol., 89:541-551, 2016; PubMed: 26912815; DOI: 10.1124/mol.115.103036

実験手法

X-RAY DIFFRACTION (2.76 Å)