5EW2

Human thrombin sandwiched between two DNA aptamers: HD22 and HD1-deltaT12

5EW2 の概要

• エントリーDOI: 10.2210/pdb5ew2/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000020
• 分子名称: thrombin light chain, Thrombin heavy chain, HD22 (27mer), ... (8 entities in total)
• 機能のキーワード: protein-dna complex, blood coagulation, dna aptamer, dna-inhibitor, g-quadruplex, duplex-quadruplex junction, serine protease, hydrolase, abasic furan, hydrolase-dna complex, protein/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 47725.30

構造登録者

Pica, A.,Russo Krauss, I.,Parente, V.,Sica, F. (登録日: 2015-11-20, 公開日: 2016-11-30, 最終更新日: 2020-07-29)

• 主引用文献: Pica, A.,Russo Krauss, I.,Parente, V.,Tateishi-Karimata, H.,Nagatoishi, S.,Tsumoto, K.,Sugimoto, N.,Sica, F.; Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.; Nucleic Acids Res., 45:461-469, 2017; PubMed: 27899589; DOI: 10.1093/nar/gkw1113

実験手法

X-RAY DIFFRACTION (3.59 Å)