5EUD

S1P Lyase Bacterial Surrogate bound to N-(1-(4-(3-hydroxyprop-1-yn-1-yl)phenyl)-2-((4-methoxy-2,5-dimethylbenzyl)amino)ethyl)-5-methylisoxazole-3-carboxamide

Summary for 5EUD

• Entry DOI: 10.2210/pdb5eud/pdb
• Related: 5EUE
• Descriptor: Putative sphingosine-1-phosphate lyase, PHOSPHATE ION, ~{N}-[(1~{S})-2-[(4-methoxy-2,5-dimethyl-phenyl)methylamino]-1-[4-(3-oxidanylprop-1-ynyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide, ... (4 entities in total)
• Functional Keywords: s1p lyase bacterial surrogate, lyase
• Biological source: Symbiobacterium thermophilum (strain T / IAM 14863)
• Total number of polymer chains: 2
• Total formula weight: 112567.08

Authors

Argiriadi, M.A.,Banach, D.,Radziejewska, E.,Marchie, S.,DiMauro, J.,Dinges, J.,Dominguez, E.,Hutchins, C.,Judge, R.A.,Queeney, K.,Wallace, G.,Harris, C.M. (deposition date: 2015-11-18, release date: 2016-03-16, Last modification date: 2023-11-15)

• Primary citation: Argiriadi, M.A.,Banach, D.,Radziejewska, E.,Marchie, S.,DiMauro, J.,Dinges, J.,Dominguez, E.,Hutchins, C.,Judge, R.A.,Queeney, K.,Wallace, G.,Harris, C.M.; Creation of a S1P Lyase bacterial surrogate for structure-based drug design.; Bioorg.Med.Chem.Lett., 26:2293-2296, 2016; PubMed: 27013389; DOI: 10.1016/j.bmcl.2016.02.084

Experimental method

X-RAY DIFFRACTION (2.24 Å)