Crystal Structure of human Tankyrase-1 bound to K-756

Summary for 5ETY

DescriptorTankyrase-1, ZINC ION, 3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-1,4-dihydroquinazolin-2-one, ... (4 entities in total)
Functional Keywordstankyrase, inhibitor, non-competitive, wnt signal, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm O95271
Total number of polymer chains4
Total molecular weight119151.46
Takahashi, Y.,Miyagi, H.,Suzuki, M.,Saito, J. (deposition date: 2015-11-18, release date: 2016-06-22, Last modification date: 2016-07-20)
Primary citation
Okada-Iwasaki, R.,Takahashi, Y.,Watanabe, Y.,Ishida, H.,Saito, J.,Nakai, R.,Asai, A.
The Discovery and Characterization of K-756, a Novel Wnt/ beta-Catenin Pathway Inhibitor Targeting Tankyrase
Mol.Cancer Ther., 15:1525-1534, 2016
PubMed: 27196752 (PDB entries with the same primary citation)
DOI: 10.1158/1535-7163.MCT-15-0938
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.29930.6%3.9%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution