5ETY
Crystal Structure of human Tankyrase-1 bound to K-756
Summary for 5ETY
Entry DOI | 10.2210/pdb5ety/pdb |
Descriptor | Tankyrase-1, ZINC ION, 3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-1,4-dihydroquinazolin-2-one, ... (4 entities in total) |
Functional Keywords | tankyrase, inhibitor, non-competitive, wnt signal, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 119151.46 |
Authors | Takahashi, Y.,Miyagi, H.,Suzuki, M.,Saito, J. (deposition date: 2015-11-18, release date: 2016-06-22, Last modification date: 2024-03-20) |
Primary citation | Okada-Iwasaki, R.,Takahashi, Y.,Watanabe, Y.,Ishida, H.,Saito, J.,Nakai, R.,Asai, A. The Discovery and Characterization of K-756, a Novel Wnt/ beta-Catenin Pathway Inhibitor Targeting Tankyrase Mol.Cancer Ther., 15:1525-1534, 2016 Cited by PubMed: 27196752DOI: 10.1158/1535-7163.MCT-15-0938 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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