5ESB
Crystal structure of a genotype 1a/3a chimeric HCV NS3/4A protease in complex with Vaniprevir
Summary for 5ESB
| Entry DOI | 10.2210/pdb5esb/pdb |
| Related | 5EPN 5EPY 5EQQ 5EQR 5EQS 5ETX |
| Descriptor | NS3 protease, ZINC ION, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | vaniprevir, drug resistance, hcv protease inhibitor, genotype 3, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Hepatitis C virus |
| Total number of polymer chains | 1 |
| Total formula weight | 21431.54 |
| Authors | Soumana, D.,Yilmaz, N.K.,Ali, A.,Prachanronarong, K.L.,Schiffer, C.A. (deposition date: 2015-11-16, release date: 2016-11-30, Last modification date: 2023-09-27) |
| Primary citation | Soumana, D.I.,Kurt Yilmaz, N.,Ali, A.,Prachanronarong, K.L.,Schiffer, C.A. Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease. J.Am.Chem.Soc., 138:11850-11859, 2016 Cited by PubMed: 27512818DOI: 10.1021/jacs.6b06454 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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