5ES1

CRYSTAL STRUCTURE OF MICROTUBULE AFFINITY-REGULATING KINASE 4 CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE INHIBITOR

5ES1 の概要

• エントリーDOI: 10.2210/pdb5es1/pdb
• 分子名称: MAP/microtubule affinity-regulating kinase 4, ~{N}-[(1~{R},6~{R})-6-azanyl-2,2-bis(fluoranyl)cyclohexyl]-5-ethyl-4-[6-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide (3 entities in total)
• 機能のキーワード: mark4 par-1 serine/threonine protein kinase11, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q96L34
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38092.83

構造登録者

Sack, J.S. (登録日: 2015-11-16, 公開日: 2015-12-02, 最終更新日: 2023-09-27)

• 主引用文献: Sack, J.S.,Gao, M.,Kiefer, S.E.,Myers, J.E.,Newitt, J.A.,Wu, S.,Yan, C.; Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor.; Acta Crystallogr F Struct Biol Commun, 72:129-134, 2016; PubMed: 26841763; DOI: 10.1107/S2053230X15024747

実験手法

X-RAY DIFFRACTION (2.8 Å)