5EQH

Human GLUT1 in complex with inhibitor (2~{S})-3-(2-bromophenyl)-2-[2-(4-methoxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide

5EQH の概要

• エントリーDOI: 10.2210/pdb5eqh/pdb
• 関連するPDBエントリー: 5EQG 5EQI
• 分子名称: Solute carrier family 2, facilitated glucose transporter member 1, (2~{S})-3-(2-bromophenyl)-2-[2-(4-methoxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide (2 entities in total)
• 機能のキーワード: mfs transporter, glucose transporter, transport protein-inhibitor complex, transport protein/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54620.80

構造登録者

Kapoor, K.,Finer-Moore, J.,Pedersen, B.P.,Caboni, L.,Waight, A.B.,Hillig, R.,Bringmann, P.,Heisler, I.,Muller, T.,Siebeneicher, H.,Stroud, R.M. (登録日: 2015-11-12, 公開日: 2016-04-13, 最終更新日: 2023-09-27)

• 主引用文献: Kapoor, K.,Finer-Moore, J.S.,Pedersen, B.P.,Caboni, L.,Waight, A.,Hillig, R.C.,Bringmann, P.,Heisler, I.,Muller, T.,Siebeneicher, H.,Stroud, R.M.; Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.; Proc.Natl.Acad.Sci.USA, 113:4711-4716, 2016; PubMed: 27078104; DOI: 10.1073/pnas.1603735113

実験手法

X-RAY DIFFRACTION (2.99 Å)