5EQH

Human GLUT1 in complex with inhibitor (2~{S})-3-(2-bromophenyl)-2-[2-(4-methoxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001666	biological_process	response to hypoxia
A	0001674	cellular_component	female germ cell nucleus
A	0001917	cellular_component	photoreceptor inner segment
A	0001939	cellular_component	female pronucleus
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005355	molecular_function	glucose transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005901	cellular_component	caveola
A	0005911	cellular_component	cell-cell junction
A	0007417	biological_process	central nervous system development
A	0007565	biological_process	female pregnancy
A	0014704	cellular_component	intercalated disc
A	0015911	biological_process	long-chain fatty acid import across plasma membrane
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0019852	biological_process	L-ascorbic acid metabolic process
A	0019900	molecular_function	kinase binding
A	0021987	biological_process	cerebral cortex development
A	0022857	molecular_function	transmembrane transporter activity
A	0030018	cellular_component	Z disc
A	0030496	cellular_component	midbody
A	0030864	cellular_component	cortical actin cytoskeleton
A	0031982	cellular_component	vesicle
A	0032868	biological_process	response to insulin
A	0033300	molecular_function	dehydroascorbic acid transmembrane transporter activity
A	0042149	biological_process	cellular response to glucose starvation
A	0042383	cellular_component	sarcolemma
A	0042470	cellular_component	melanosome
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0045121	cellular_component	membrane raft
A	0045202	cellular_component	synapse
A	0045494	biological_process	photoreceptor cell maintenance
A	0046323	biological_process	glucose import
A	0055056	molecular_function	D-glucose transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0065003	biological_process	protein-containing complex assembly
A	0070062	cellular_component	extracellular exosome
A	0070837	biological_process	dehydroascorbic acid transport
A	0071260	biological_process	cellular response to mechanical stimulus
A	0071474	biological_process	cellular hyperosmotic response
A	0072562	cellular_component	blood microparticle
A	0098708	biological_process	glucose import across plasma membrane
A	0098793	cellular_component	presynapse
A	0150104	biological_process	transport across blood-brain barrier
A	1904016	biological_process	response to Thyroglobulin triiodothyronine
A	1904659	biological_process	glucose transmembrane transport
A	1990350	cellular_component	glucose transporter complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 5RF A 501

Chain	Residue
A	SER80
A	THR137
A	GLN282
A	PHE379
A	TRP388
A	GLY408
A	ASN411
A	TRP412

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Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	17
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. SLFVVERAGRRtlhli.G

Chain	Residue	Details
A	SER324-GLY340

---

site_id	PS00217
Number of Residues	26
Details	SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. IiGVYcGLttgfvpmYvgEvsptalR

Chain	Residue	Details
A	ILE128-ARG153

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24847886

Chain	Residue	Details
A	MET1-ARG11
A	ASN88-PHE90
A	GLY145-ALA155
A	CYS207-PRO271
A	GLU329-ARG334
A	PHE389-PRO401
A	LYS451-VAL492

---

site_id	SWS_FT_FI2
Number of Residues	21
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	LEU12-ILE33

---

site_id	SWS_FT_FI3
Number of Residues	74
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:24847886

Chain	Residue	Details
A	ASN34-SER66
A	SER113-GLU120
A	ASP177-LEU185
A	SER294-PRO306
A	ALA356-SER365
A	GLN423-CYS429

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	LEU67-VAL87

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	GLY91-PHE112

---

site_id	SWS_FT_FI6
Number of Residues	23
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	MET121-VAL144

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	LEU156-LEU176

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	TRP186-PHE206

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	ILE272-TYR293

---

site_id	SWS_FT_FI10
Number of Residues	21
Details	TRANSMEM: Helical; Name=8

Chain	Residue	Details
A	VAL307-VAL328

---

site_id	SWS_FT_FI11
Number of Residues	20
Details	TRANSMEM: Helical; Name=9

Chain	Residue	Details
A	THR335-LEU355

---

site_id	SWS_FT_FI12
Number of Residues	22
Details	TRANSMEM: Helical; Name=10

Chain	Residue	Details
A	TYR366-TRP388

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	TRANSMEM: Helical; Name=11

Chain	Residue	Details
A	ALA402-PHE422

---

site_id	SWS_FT_FI14
Number of Residues	20
Details	TRANSMEM: Helical; Name=12

Chain	Residue	Details
A	GLY430-PHE450

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27078104, ECO:0007744|PDB:5EQI

Chain	Residue	Details
A	THR137
A	GLN282
A	TRP388

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:24847886, ECO:0007744|PDB:4PYP

Chain	Residue	Details
A	ASN288
A	ASN317
A	GLU380

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:27078104

Chain	Residue	Details
A	ASN411

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	SITE: Not glycosylated => ECO:0000269|PubMed:3839598

Chain	Residue	Details
A	ASN411

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET1

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC/PRKCB => ECO:0000269|PubMed:25982116

Chain	Residue	Details
A	SER226

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER465

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	THR478

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER490

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:3839598

Chain	Residue	Details
A	ASN45

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