5EPM

Ceratotoxin variant in complex with specific antibody Fab fragment

Summary for 5EPM

• Entry DOI: 10.2210/pdb5epm/pdb
• Descriptor: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, Beta-theraphotoxin-Cm1a, ... (4 entities in total)
• Functional Keywords: ceratotoxin, random mutagenesis, nav1.7 ion chanel, toxin-immune system complex, toxin/immune system
• Biological source: Mus musculus; More
• Cellular location: Secreted : P84507
• Total number of polymer chains: 6
• Total formula weight: 103716.28

Authors

Strop, P.,Shcherbatko, A.,Rossi, A. (deposition date: 2015-11-11, release date: 2016-05-04, Last modification date: 2023-09-27)

• Primary citation: Shcherbatko, A.,Rossi, A.,Foletti, D.,Zhu, G.,Bogin, O.,Galindo Casas, M.,Rickert, M.,Hasa-Moreno, A.,Bartsevich, V.,Crameri, A.,Steiner, A.R.,Henningsen, R.,Gill, A.,Pons, J.,Shelton, D.L.,Rajpal, A.,Strop, P.; Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.; J.Biol.Chem., 291:13974-13986, 2016; PubMed: 27129258; DOI: 10.1074/jbc.M116.725978

Experimental method

X-RAY DIFFRACTION (1.75 Å)