5EK0

Human Nav1.7-VSD4-NavAb in complex with GX-936.

Summary for 5EK0

• Entry DOI: 10.2210/pdb5ek0/pdb
• Descriptor: Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (3 entities in total)
• Functional Keywords: membrane protein, ion channel, voltage-gated sodium channel, small molecule antagonist, metal transport
• Biological source: Arcobacter butzleri, Homo sapiens
• Total number of polymer chains: 4
• Total formula weight: 155032.46

Authors

Ahuja, S.,Mukund, S.,Starovasnik, M.A.,Koth, C.M.,Payandeh, J. (deposition date: 2015-11-03, release date: 2015-12-23, Last modification date: 2023-09-27)

• Primary citation: Ahuja, S.,Mukund, S.,Deng, L.,Khakh, K.,Chang, E.,Ho, H.,Shriver, S.,Young, C.,Lin, S.,Johnson, J.P.,Wu, P.,Li, J.,Coons, M.,Tam, C.,Brillantes, B.,Sampang, H.,Mortara, K.,Bowman, K.K.,Clark, K.R.,Estevez, A.,Xie, Z.,Verschoof, H.,Grimwood, M.,Dehnhardt, C.,Andrez, J.C.,Focken, T.,Sutherlin, D.P.,Safina, B.S.,Starovasnik, M.A.,Ortwine, D.F.,Franke, Y.,Cohen, C.J.,Hackos, D.H.,Koth, C.M.,Payandeh, J.; Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.; Science, 350:aac5464-aac5464, 2015; PubMed: 26680203; DOI: 10.1126/science.aac5464

Experimental method

X-RAY DIFFRACTION (3.53 Å)